COVID-19 Vaccine for Children under 5: Description

Pfizer/BioNTech today announced that data on a three-dose Covid-19 vaccine for children 6 months to less than 5 years old has favorable immune responses with minimal side effects. As reported in Forbes According to Robert Hart, in contrast to the two-dose regimens previously studied, the three-dose regimen produced a similar immune response to the two-dose regimen between 18 and 25 years of age and had a robust safety profile.

This comes at a time when many states are seeing a surge in cases of Covid-19 and some areas in the northeast have been decided to return to their original state. “High Alert” level. Most parts of the country have lifted nearly all Covid-19 mitigation measures, including masking and testing, and almost all jurisdictions have not required either, despite a significant increase in the number of daily cases as well as current hospitalizations.

Parents of 18 million children under the age of 5 in the United States are eagerly awaiting approval of a COVID-19 vaccine for their children. A two-dose Pfizer vaccine regimen administered at very low doses (3 micrograms) in infants 6 months of age to infants under 5 years of age 3 weeks apart did not produce sufficient immune responses to submit to FDA. For emergency use authorization. Instead of starting the trial from scratch with a higher-dose, two-dose regimen, the researchers decided instead to extend the trial with a third vaccine at the same dose. The news that this extra capacity adds significant protection is reason to celebrate.

Significant news of the success of today’s Pfizer/BioNtech data on a three-dose Covid-19 vaccine for the youngest age group, but it comes almost a month later. moderna shared favorable data on two doses of COVID-19 for children 6 months to under 6 years old. Moderna, an mRNA vaccine with a similar mechanism of action to the Pfizer vaccine, doses are much higher in all age groups. Adults (18 years and older) provide 100 micrograms of mRNA per dose of Moderna vaccine. And for the youngest age group, 25 micrograms It is given per dose every 4 weeks.

Adults (12 years and older by dose) Pfizer vaccine contains 30 micrograms of mRNA, and the first two doses are recommended 3 weeks apart. of the two companies dosing difference This may explain why people vaccinated with Moderna in the first few months of the launch of these two vaccines had a stronger immune response than those vaccinated with Pfizer/BioNtech and therefore better protected .

Data also appeared between the ages of 5 and 11, causing problems with Pfizer’s dosing. This age group received most of the vaccine in the early stages of the large-scale omicron surge from November 2021 to January 2022, and although the safety profile was good, the response to protect against disease was not optimal. like i covered Forbes, a low-dose, 10-microgram Pfizer vaccine for this age group showed minimal protection against mild illness when the earliest omicron surge peaked last winter. It provided excellent protection against serious illness and hospitalization and continues to see these benefits of vaccines while the current Omicron submutation is on the rise. Children 5-11 years of age who received a second dose of coronavirus vaccine more than 5 months ago are now encouraged to get the vaccine. booster With the same dose of 10 micrograms.

Moderna’s COVID-19 vaccine data for the youngest eligible group have not yet been approved for emergency use. Submission of trial results Submitted to FDA on May 9, 2022. The FDA will review both Pfizer/BioNTech data and Moderna data for the youngest person needing a vaccine in June, and hopes to grant emergency use approval for either or both of the following: This vaccine will be available until the beginning of this summer.

all Kaiser Family Foundation According to a January 2022 survey, only 30% of parents with children under the age of five said they plan to vaccinate their children as soon as the vaccine is available. The current climate of increasing cases in this country and many other places may remind us that we are far from this pandemic forest, and what we can do to protect vulnerable people, including infants and young children. The more of these, the better. We will all be apart.


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